An artificial pancreas may improve overnight blood-glucose control and reduce the risk of nocturnal hypoglycaemia in adults with type 1 diabetes, according to new studies.
The close-loop insulin delivery system automatically computes insulin dose according to glucose levels detected by a sensor.
Previous studies have shown that the system is effective in children and adolescents, but its effectiveness in adults is unknown.
For the studies, a team of researchers at the University of Cambridge enrolled ten men and 14 women aged 18-65.
The studies were designed to compare the safety and efficacy of overnight closed-loop insulin delivery with conventional insulin pump therapy in adults with type 1 diabetes.
The results of the studies revealed that the time spent with blood-glucose levels in the target range increased by up to 28% during overnight closed loop insulin delivery.
Closed-loop delivery also lowered glucose variability overnight and significantly reduced the time spent hyperglycaemic.
The authors concluded that overnight closed loop delivery can operate safely, effectively, and consistently across different age groups, insulin sensitivities and lifestyle conditions.
In addition, it may allow more flexible lifestyles in conjunction with improved glycaemic control for people with type 1 diabetes.