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December 19, 2010

New Genetic Markers Could Improve Accuracy of Prostate Cancer Treatment

Scientists from deCODE genetics have discovered genetic markers that improve the accuracy of prostate specific antigen (PSA) testing for detecting prostate cancer. The scientists discovered a set of single-letter variations in the sequence of the human genome (SNPs), which can affect i

By cms admin

Scientists from deCODE genetics have discovered genetic markers that improve the accuracy of prostate specific antigen (PSA) testing for detecting prostate cancer.

The scientists discovered a set of single-letter variations in the sequence of the human genome (SNPs), which can affect individual baseline levels of prostate specific antigen, or PSA.

According to the scientists, an analysis of four SNPs can be utilised to obtain a personalised PSA threshold, which would identify men that would be more likely to have a positive biopsy and for whom PSA testing should be recommended.

deCODE CEO, Kari Stefansson, said the reported SNPs enable the personalisation of PSA thresholds, changing the recommendation to biopsy for a substantial proportion of men.

“Moreover, the discriminatory power of testing for these SNPs is highest when done in tandem with the SNPs associated directly with risk of the disease measured by our deCODE Prostate cancer test, ” he added

For the study, researchers analysed SNPs in tens of thousands of men with and without prostate cancer to obtain the four SNPs correlated with PSA levels.

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