Researchers in Denmark have developed a new assay to test for the tumour markers that point to bladder cancer.
The Danish Cancer Society and the Herlev University Hospital of Copenhagen teamed up to modify the MS-MLPA (methylation specific-multiplex ligation-dependent probe amplification) assay so it can be used with short synthetic probes.
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Paired tumour and urine samples showed identical marker patterns in most cases, leading researchers to suggest that it can be used for non-invasive diagnosis and disease monitoring.
MS-MLPA screens multiple target sequences simultaneously – however, it is not available commercially, and probe design has been limited by the difficulty of synthesising long nucleotides.
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