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August 1, 2010

MODS Proves Best for Tuberculosis Detection

A microscopic-observation drug-susceptibility (MODS) technique that uses gastric aspirate specimens is the best test for high-risk children suffering with tuberculosis, an international team of researchers has found. According to the Tulane University School of Public Health and Tropical

By cms admin

A microscopic-observation drug-susceptibility (MODS) technique that uses gastric aspirate specimens is the best test for high-risk children suffering with tuberculosis, an international team of researchers has found.

According to the Tulane University School of Public Health and Tropical Medicine team, MODS can spot typical growth patterns in culture broth in resource-poor areas with limited laboratory capabilities.

The study was conducted at two hospitals in Lima and Peru between 2002 and 2007, and involved 456 children aged 12 or younger. It compared the results of several different tests on specimens from MODS, Lowenstein-Jensen culture using auramine stain testing and polymerase chain reaction (PCR).

PCR testing was not found to be specific enough for routine diagnosis, but duplicate PCR was useful to recognise the high-risk children most likely to have positive tuberculosis cultures.

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