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August 12, 2010

MIT Makes Progress on Light-Based Blood-Glucose Monitor

Researchers at MIT's Spectroscopy Laboratory are developing a light-based device that can help people with type I diabetes to measure their blood-glucose levels without skin pricking. The device uses Raman spectroscopy, a method that detects the chemical compounds in blood by measuring t

By cms admin

Researchers at MIT’s Spectroscopy Laboratory are developing a light-based device that can help people with type I diabetes to measure their blood-glucose levels without skin pricking.

The device uses Raman spectroscopy, a method that detects the chemical compounds in blood by measuring the frequency of vibrations of the bonds that hold the molecule together.

Patients are able to measure their blood glucose levels by scanning their arm or finger near the infrared light.

Researchers in the Spectroscopy lab have been working on this light-based technology for 15 years, mainly because of a major obstacle where infrared rays only penetrated half a millimetre below the skin, measuring the glucose in interstitial fluid rather than the blood.

The team came up with a solution by creating an algorithm which gives blood-glucose levels based on the interstitial fluid.

This algorithm had its own issues – it could not calculate the blood glucose correctly immediately after the patients consumed sugary foods or drinks.

To solve this problem, the researchers created a new calibration method known as dynamic concentration correction (DCC), which measures the rate glucose diffuses from the blood into the interstitial fluid.

A study involving ten volunteers showed that DCC-calibrated Raman spectroscopy boosted the blood glucose accuracy up to 30%.

A clinical study of DCC-calibrated spectroscopy in healthy volunteers is being planned for later in 2010.

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