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August 24, 2010

Genetic Test Could Herald TB Breakthrough

Scientists are getting closer to developing a genetic blood test that could determine whether a patient carrying latent form tuberculosis (TB) will develop full-blown TB. Researchers compared the genes of patients with active and latent TB with healthy subjects to identify the "transcrip

By cms admin

Scientists are getting closer to developing a genetic blood test that could determine whether a patient carrying latent form tuberculosis (TB) will develop full-blown TB.

Researchers compared the genes of patients with active and latent TB with healthy subjects to identify the “transcriptional signature”, the clusters of genes common to patients with latent TB and active TB.

They successfully found out that the neutrophil-driven interferon-inducible gene profile was common these patients.

Study leader Dr Anne O’Garra, of the MRC National Institute for Medical Research, said that being able to predict which TB carriers will develop the full-blown disease would have major ramifications for stopping the global epidemic.

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