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August 25, 2010

Sirtex’s Colorectal Cancer Microspheres Prove Effective

Sirtex has announced that its radioactive yttrium-90-labelled resin microspheres appear to be a safe and effective treatment for patients with colorectal cancer liver metastases who have not responded to chemotherapy. Selective Internal Radiation Therapy (SIRT) uses microspheres implante

By cms admin

Sirtex has announced that its radioactive yttrium-90-labelled resin microspheres appear to be a safe and effective treatment for patients with colorectal cancer liver metastases who have not responded to chemotherapy.

Selective Internal Radiation Therapy (SIRT) uses microspheres implanted by interventional radiologists that target radiation on tumours while avoiding the exposure of healthy liver tissue.

The Phase II trial involved 52 patients with liver metastases from colorectal cancer, who were heavily pre-treated with at least three chemotherapy regiments.

The results showed that in one patient (2%) the liver tumours completely disappeared. In 11 patients (22%) the tumours shrank at least 30% in size, and in two patients (4%) they shrank sufficiently to enable surgery. Twelve patients (24%) had stable disease.

The median overall survival was 12.6 months for the patients in the trial, however, the 24 patients (48%) who had responded to therapy had significantly longer survival compared to non-responders.

The study was conducted by the Italian Society of Locoregional Therapies in Oncology at the Regina Elena National Cancer Institute in Rome, the University of Bologna, the University of Udine and the Cancer Institute of Naples in Italy.

Sirtex Medical’s SIR-Spheres are the only FDA-approved microsphere therapy for colorectal cancer liver metastases.

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