Osteoporosis is a disease in which the density and quality of bone are reduced over time. Osteoporosis is often referred to as a ‘silent’ disease as the loss of bone occurs progressively, and often there are no symptoms until the first fracture occurs.

Around the world, one in three women and one in five men are at risk of an osteoporotic fracture. The morbidity and mortality associated with osteoporotic fractures make osteoporosis a global health burden, second only to cardiovascular disease. As the world’s population ages, the burden of the disease is expected to increase.

GlobalData epidemiologists forecast that the total prevalent cases of osteoporosis in the seven major markets (7MM: US, France, Germany, Italy, Spain, UK, and Japan) will increase from 45,617,583 cases in 2017 to 52,482,628 cases in 2027, at an annual growth rate (AGR) of 1.50. Of the 7MM, the US is expected to see the largest growth, from 13,347,321 cases in 2017 to 16,307,141 cases in 2027, at an AGR of 2.22%. Italy is expected to have the lowest AGR of 0.99%. GlobalData forecasts that all markets will see an increase in the total prevalent cases of osteoporosis during the forecast period.

In the 7MM, there was a general trend of the number of cases increasing with age. The age group from 30–39 years had the lowest number of total prevalent cases in the 7MM, making up only 1.61% of the total. The highest number of total prevalent cases was in the age group 70–79 years, making up 27.92% of the total prevalent cases.

Osteoporosis is a debilitating condition in terms of quality of life impact and progressive deterioration in bone health. As osteoporosis typically occurs in the population at ages 30 years and above, the burden of osteoporosis is expected to increase due to the ageing global population. Elderly people are also at greater risk from other comorbid medical conditions, which increases the complexity in managing this condition. Treatment priorities should be aligned towards early diagnosis and prevention of bone fracture to address this growing problem in an ageing population.

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