Clinical trials that focus on asthma treatments are pivotal, as there is no long-term effective therapy for the condition.

GlobalData analysed the number of clinical trials examining asthma drug treatments with start dates between 1 January 2010 and 11 February 2019.

Asthma is a long-term inflammatory lung condition that causes difficulty in breathing and can affect people of all ages. Common symptoms include wheezing, breathlessness, tightness in the chest, and persistent coughing.

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Clinical trials that focus on asthma treatments are pivotal, as there is no long-term effective therapy for the condition.

The majority of clinical trials were in Phase II (35.9%), with industry sponsors accounting for 61.1% of trials conducted. A significant proportion of clinical trials were conducted in the US (38.5%) followed by the UK (19.2%).

Top five asthma drugs by percentage of clinical trials

Fluticasone propionate plus salmeterol xinafoate had the highest percentage of trials within a nine-year span (26.4%). This treatment was first submitted to the US Food and Drug Administration by GlaxoSmithKline and was approved in 1999.

Fluticasone propionate acts as an anti-inflammatory drug, decreasing inflammation in the lungs, while salmeterol xinafoate is a long-acting beta adrenoceptor agonist that helps expand the trachea.

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AstraZeneca’s budesonide plus formoterol fumarate combination followed with 24.3% of clinical trials. Budesonide has an effect on the major mediators of trachea inflammation while formoterol fumarate is a beta receptor agonist, which increases cyclic adenonsine monophosphate (cAMP) levels directly, causing relaxation of bronchial smooth muscle tissue.

Montelukast sodium (21.7%), omalizumab (18.7%), and flovent (8.9%) were the remaining top five asthma drugs, by the number of clinical trials. These drugs are all also immediate therapy solutions for the acute treatment of asthma.

Top 5 drugs investigated for asthma

Source: GlobalData